Efficient synthesis of ethyl 4-[N-methyl-N-(2,3-aziridinyl)amino]benzoate and diethyl N-{4-[N-methyl-N-(2,3-aziridinyl)amino]benzoyl}-L-glutamate
نویسندگان
چکیده
منابع مشابه
N-Ethyl-4-methyl-N-(3-methylphenyl)benzenesulfonamide
The title compound, C(16)H(19)NO(2)S, crystallizes with two crystallographically independent mol-ecules in the asymmetric unit in which the dihedral angles between the planes defined by the aromatic rings are 35.3 (2) and 42.5 (2)°. In the crystal, inter-molecular C-H⋯O hydrogen bonds stabilize the packing.
متن کامل4-Methyl-N-phenylbenzenesulfonamide
In the title compound, C(13)H(13)NO(2)S, the dihedral angle between the aromatic rings is 68.4 (1)°. In the crystal, the molecules are linked into inversion dimers by pairs of N-H⋯O hydrogen bonds. The unit cell of this compound was reported previously [Oh et al. (1985 ▶). Chung. Kwa. Yong. (Chung. J. Sci.), 12, 67] but no atomic coordinates were established in the earlier study.
متن کاملN-(2-Bromophenyl)-4-methyl-N-(4-methylphenylsulfonyl)benzenesulfonamide
In the title compound, C(20)H(18)BrNO(4)S(2), the mean planes formed by the toluene substituents are inclined at a dihedral angle of 45.34 (8)°. The bromo-benzene group is disordered over two positions with an occupancy ratio of 0.74:0.26, resulting in two conformations of the ring; the two rings are oriented at a dihedral angle of 6.6 (6)° with each other. In the crystal structure, weak C-H⋯O ...
متن کاملN-(2,3-Dimethylphenyl)-4-methyl-N-(4-methylphenylsulfonyl)benzenesulfonamide
In the title compound, C(22)H(23)NO(4)S(2), the dihedral angles between the dimethyl-phenyl ring and the two methyl-phenyl rings are 41.19 (15) and 20.50 (17)°; the dihedral angle between the methyl-phenyl rings is 48.11 (14)°. The C-N-S-C torsion angles are -87.6 (2) and 77.43 (18)°. The only possible directional inter-actions in the crystal are very weak C-H⋯π inter-actions and very weak π-π ...
متن کامل6-Chloro-N 4-methyl-N 4-phenylpyrimidine-4,5-diamine
In the title compound, C(11)H(11)ClN(4), the dihedral angle between the aromatic rings is 66.47 (8)°. In the crystal, mol-ecules are linked by N-H⋯N hydrogen bonds, generating C(5) chains propagating in [010]. Slipped aromatic π-π stacking between centrosymmetrically related pairs of pyrim-idine rings also occurs [centroid-centroid separation = 3.7634 (12)Å and slippage = 1.715 Å].
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ژورنال
عنوان ژورنال: Journal of Chinese Pharmaceutical Sciences
سال: 2010
ISSN: 1003-1057
DOI: 10.5246/jcps.2010.02.021